Throughout the entire franchise,Mass Effectplayers are introduced to interesting companion after companion. Not all of them will likely be in, or evenbe alive inMass Effect 4, but many do survive in the best playthroughs. No matter what, though, there is one companion who will always die: Thane Krios.
First met inMass Effect 2, Thane is a Drell Assassin who players recruit for the cause, and assuming he survivesMass Effect 2’s Suicide Mission, his story carries over intoMass Effect 3. It is heart-breaking nonetheless, because as players learn, he has an incurable disease known as Kepral’s Syndrome.
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Mass Effect: What is Kepral’s Syndrome
Kepral’s Syndrome is a genetic disease that can only impact the Drell, but unlike theGenophage in the Krograns, it’s entirely natural and man-made. It is named after the Drell, Kepral, who first diagnosed it. Essentially, the disease erodes a Drell’s ability to consume oxygen and stops blood from producing hemoglobin. It has been determined that Kepral’s Syndrome comes from cumulative long-term exposure to humid climates. Potentially, there is a connection here with a Drell’s lizard-like features. Lizards are often sensitive to climate and weather changes, and it would make sense here.
Unfortunately, it has become more and more of an issue for the Drell species inMass Effect. It shortened their lifespan drastically, became the leading cause of death among Drell, and is not a pleasant way to go—with most losing the ability to breathe first, making each and every breath harder than the last until complete suffocation.
As a disease in theMass Effectuniverse, there are a few other known key factors: it is not hereditary, it is noncommunicable, and it is not contagious. Drell born in humid climates have a higher chance of getting it.
Mass Effect: Can Thane’s Kepral’s Syndrome Be Cured?
No cure for Kepral’s Syndrome exists, but the Hanar have been working toward finding one for some time. This is important for a couple of reasons. It should be noted that the disease was first conceptualized as curable, given the advancements of technology in theMass Effectuniverse. However, by making it uncurable,Thane Krios' characteradds a new layer of humanity to the game and also shows how even science in a far-future has its limitations.
It was pitched that perhaps the Reapers or Cerberus could cure it and use it as bait forCommander Shepard, but it didn’t pan out, reportedly, due to project limitations. Still, the whole idea of an uncurable disease in an assassin who has disassociated himself from his own body in a universe without a lot of spiritual humanity really takes his character to the next level.
As such, Commander Shepard cannotsave Thane inMass Effect 3. Shepard will eventually visit him in the hospital, but Thane is no longer in any condition to fight—needing daily treatment. Still, Thane (assuming he survivesME2) will fight and be stabbed by Kai Leng. Before his death, Thane will say a prayer of forgiveness, not for his past which he has already asked, but for Shepard.
